Mapk1 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comMapk1 CLIA Kit for Rat(Rattus norvegicus)

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Mapk1 (Gene name),

Mitogen-activated protein kinase 1 (Protein name ), MK01_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapk1(Erk2;Mapk;Prkm1);

Protein name:

Mitogen-activated protein kinase 1(MAP kinase 1;MAPK 1);

Alternative:

Extracellular signal-regulated kinase 2(ERK-2);ERT1;Mitogen-activated protein kinase 2(MAP kinase 2;MAPK 2);MAP kinase isoform p42(p42-MAPK);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with ARHGEF2, NISCH, MORG1 and HSF4 (By similarity). Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads stlto nuclear location and MAPK1 activation. Interacts with ARRB2. Interacts with ADAM15 (By similarity). Interacts with NEK2.

Function:

Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.

Subcellular Location:

Nucleus Cytoplasm cytoskeleton centrosome

Protein Attributes:

Sequence length:

358

Sequence:

50:

100:

150:

200:

250:

300:

350:

358:

RFQPGYRS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P63086

String:

P63086

KEGG:

rno:116590

Pfam:

PF00069

UniGene:

Rn.34914

Uniprot:

P63086

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ELISA Kit for Rat MAP kinase 1

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E1206m

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ELISA Kit for Rat MAP kinase 1

Cat.:

E1206r

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96T

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ELISA Kit for Rat MAP kinase 1

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E1206h

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ELISA Kit for Rat MAP kinase 1

Cat.:

E1206b

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96T

CLIA Kit for Rat MAP kinase 1

Cat.:

U1206h

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CLIA Kit for Rat MAP kinase 1

Cat.:

U1206m

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96T

CLIA Kit for Rat MAP kinase 1

Cat.:

U1206r

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96T

CLIA Kit for Rat MAP kinase 1

Cat.:

U1206b

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96T

Polyclonal Antibody for Rat MAP kinase 1

Cat.:

P1206Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat MAP kinase 1

Cat.:

P1206Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat MAP kinase 1

Cat.:

P1206Rb-r

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40ug/0.2ml

Monoclonal Antibody for Rat MAP kinase 1

Protein for Rat MAP kinase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF."
Boulton T.G. , Nye S.H. , Robbins D.J. , Ip N.Y. , Radziejewska E. , Morgenbesser S.D. , DePinho R.A. , Panayotatos N. , Cobb M.H. , Yancopoulos G.D.
Cell65:663-675(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Brain.
2.

Bienvenut W.V. , von Kriegsheim A.F. , Kolch W.
Submitted (2006-08) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13; 69-75; 137-170; 193-201 AND 341-351;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Pheochromocytoma.
3.

Lubec G. , Kang S.U.
Submitted (2007-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 163-170;IDENTIFICATION BY MASS SPECTROMETRY
strain: Sprague-Dawley.
tissue: Brain.
4.

"Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation."
Seger R. , Ahn N.G. , Boulton T.G. , Yancopoulos G.D. , Panayotatos N. , Radziejewska E. , Ericsson L. , Bratlien R.L. , Cobb M.H. , Krebs E.G.
Proc. Natl. Acad. Sci. U.S.A.88:6142-6146(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOPHOSPHORYLATION
5.

"PHAS-I as a link between mitogen-activated protein kinase and translation initiation."
Lin T.-A. , Kong X. , Haystead T.A.J. , Pause A. , Belsham G.J. , Sonenberg N. , Lawrence J.C. Jr.
Science266:653-656(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION OF EIF4EBP1
6.

"Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds."
Luttrell L.M. , Roudabush F.L. , Choy E.W. , Miller W.E. , Field M.E. , Pierce K.L. , Lefkowitz R.J.
Proc. Natl. Acad. Sci. U.S.A.98:2449-2454(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2
7.

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.

"Identification of pY19-caveolin-2 as a positive regulator of insulin-stimulated actin cytoskeleton-dependent mitogenesis."
Kwon H. , Jeong K. , Pak Y.
J. Cell. Mol. Med.13:1549-1564(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CAV2
9.

"Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin."
Kwon H. , Jeong K. , Hwang E.M. , Park J.-Y. , Hong S.-G. , Choi W.-S. , Pak Y.
Biochim. Biophys. Acta1793:1325-1333(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CAV2
10.

"The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions."
Yoon S. , Seger R.
Growth Factors24:21-44(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
11.

"The ERK signaling cascade--views from different subcellular compartments."
Yao Z. , Seger R.
BioFactors35:407-416(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;REVIEW ON SUBCELLULAR LOCATION
12.

"The ERK cascade: distinct functions within various subcellular organelles."
Wortzel I. , Seger R.
Genes Cancer2:195-209(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
13.

"Atomic structure of the MAP kinase ERK2 at 2.3-A resolution."
Zhang F. , Strand A. , Robbins D. , Cobb M.H. , Goldsmith E.J.
Nature367:704-710(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
14.

"Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate."
Robinson M.J. , Harkins P.C. , Zhang J. , Baer R. , Haycock J.W. , Cobb M.H. , Goldsmith E.J.
Biochemistry35:5641-5646(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) IN COMPLEX WITH ATP
15.

"Activation mechanism of the MAP kinase ERK2 by dual phosphorylation."
Canagarajah B.J. , Khokhlatchev A. , Cobb M.H. , Goldsmith E.J.
Cell90:859-869(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
16.

"Structural basis of inhibitor selectivity in MAP kinases."
Wang Z. , Canagarajah B.J. , Boehm J.C. , Kassisa S. , Cobb M.H. , Young P.R. , Abdel-Meguid S. , Adams J.L. , Goldsmith E.J.
Structure6:1117-1128(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH INHIBITOR
17.

"Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3."
Liu S. , Sun J.P. , Zhou B. , Zhang Z.Y.
Proc. Natl. Acad. Sci. U.S.A.103:5326-5331(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-357;INTERACTION WITH DUSP6
18.

"Docking interactions induce exposure of activation loop in the MAP kinase ERK2."
Zhou T. , Sun L. , Humphreys J. , Goldsmith E.J.
Structure14:1011-1019(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-357
19.

"Molecular modeling and crystal structure of ERK2-hypothemycin complexes."
Rastelli G. , Rosenfeld R. , Reid R. , Santi D.V.
J. Struct. Biol.164:18-23(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-358 IN COMPLEX WITH INHIBITOR
20.

"Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors."
Katayama N. , Orita M. , Yamaguchi T. , Hisamichi H. , Kuromitsu S. , Kurihara H. , Sakashita H. , Matsumoto Y. , Fujita S. , Niimi T.
Proteins73:795-801(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) IN COMPLEX WITH INHIBITOR
21.

"Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase."
Ma W. , Shang Y. , Wei Z. , Wen W. , Wang W. , Zhang M.
Structure18:1502-1511(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH DCC;FUNCTION IN PHOSPHORYLATION OF DCC;INTERACTION WITH DCC;MUTAGENESIS OF GLN-117; HIS-123 AND LEU-155

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